Descending pain modulation and chronification of pain
نویسندگان
چکیده
منابع مشابه
Nicotinic modulation of descending pain control circuitry.
Along with the well-known rewarding effects, activation of nicotinic acetylcholine receptors (nAChRs) can also relieve pain, and some nicotinic agonists have analgesic efficacy similar to opioids. A major target of analgesic drugs is the descending pain modulatory pathway, including the ventrolateral periaqueductal gray (vlPAG) and the rostral ventromedial medulla (RVM). Although activating nAC...
متن کاملChronification of Pain and the Science of Pain Management
moves the joy and love of life that our Veterans deserve. Even in the most resilient Veterans with strong family and community support, inadequately managed pain can lead to depression, substance misuse, and suicide. The biospsychosocial epiphenomena of chronic pain, such as disability, obesity, social distress, and isolation further exacerbate pain’s burden on Veterans, their families, and the...
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چکیده ندارد.
15 صفحه اولDescending control of pain.
Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling) information from the viscera, skin and other organs is subject to extensive processing by a diversity of mechanisms, certain of which enhance, and certain of which inhibit, its transfer to higher centres. In this regard, a network of descending pathways projecting from cerebral structures to the DH plays a co...
متن کاملDescending control of pain.
Thanks largely to the study of the brainstem nuclei that mediate stimulation analgesia, the involvement of the monoamines in the descending control of pain is now well established. The periaqueductal grey, the raphe nuclei (NRM and DRN) and the locus coeruleus are all key brainstem sites for the control of nociceptive transmission in the spinal cord. Although the initial emphasis was on 5-HT as...
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ژورنال
عنوان ژورنال: Current Opinion in Supportive & Palliative Care
سال: 2014
ISSN: 1751-4258
DOI: 10.1097/spc.0000000000000055